Logistic regression analysis was carried out with whether OMG is complicated with TAO or not as a dependent variable, and the locus -863C > A, -238G > A and -308G > A in the TNF-α promoter region and DQA1*0103 and *0301, DQB1*0501 and *0601 and expressions of AChRAb and T-Ab as independent variables. This evidence concerns the gene TNF and thromboangiitis obliterans.