Conversely, BRN2 has been implicated in promoting an invasive and less differentiated state that is important in driving tumour progression towards metastasis, however few downstream targets of BRN2 that facilitate this phenotype have been identified (Arozarena et al., 2011, Boyle et al., 2011, Pinner et al., 2009). The gene discussed is POU3F2; the disease is neoplasm.