Conversely, constitutive BRN2 overexpression was also performed in these same cell lines and revealed a commensurate increase in both NFIB (3.8, 3.7, 2.4 fold respectively) and EZH2 (2.5, 2.3, 2.6 fold respectively) expression across all three melanoma cell lines (Fig. 2B). Here, NFIB is linked to melanoma.