Further interrogation of the TCGA melanoma database, investigating primary (101) vs. metastatic (367) derived patient tumours also reveals that relative NFIB expression is significantly increased in the metastatic tumour group (P < 0.001)(Fig. 6F) and that there is a significant correlation between BRN2 and NFIB expression within both groups (Fig. S6C). This evidence concerns the gene NFIB and neoplasm.