POU3F2 and melanoma: While the idea of phenotype switching and mutual exclusivity between these two cell types is debatable (Chapman et al., 2014, Haass et al., 2014), it is clear that BRN2 drives an invasive melanoma cell phenotype (Arozarena et al., 2011, Boyle et al., 2011, Kobi et al., 2010).