MITF and melanoma: In melanoma, heterogeneous expression of the BRN2 and MITF transcription factors has been proposed to constitute a crucial switching mechanism between invasive and proliferative phenotypes (Goodall et al., 2008, Hoek et al., 2008, Hoek and Goding, 2010, Pinner et al., 2009, Quintana et al., 2010, Thurber et al., 2011).