Specifically, NFIB expression and regulation within tumours may be key in feeding into the MITF rheostat model downstream of BRN2, whereby changes in BRN2 are able to dictate reversible changes in MITF expression through NFIB and EZH2 to a level that will allow for increased proliferation during formation, and increased migration/invasion when undergoing a switch to a more EMT-like invasive phenotype during metastasis. The gene discussed is EZH2; the disease is neoplasm.