Regarding these two polymorphisms, a previous study, performed for Polish infants with postnatal or unproven congenital HCMV infection, showed both heterozygotes and recessive homozygotes in TLR9 -1486 T>C and 2848 G>A SNPs to be at almost 4-fold increased risk of HCMV disease in an adjusted model, including HCMV DNA loads [51]. This evidence concerns the gene TLR9 and cytomegalovirus infection.