Also, since renal lesions can be adipocyte-rich and entrap renal parenchyma, vascular-rich lesions of the kidney, including angiomyolipoma and renal cell carcinoma may be included in the differential diagnosis, a task easily accomplished with the use of immunohistochemical markers including HMB45, Melan-A, cytokeratins and CD10. The gene discussed is PMEL; the disease is renal cell carcinoma.