It is not surprising, therefore, that there is solid evidence of increased oxidative stress in the airways of patients with chronic obstructive pulmonary disease (COPD), which is increased further in severe and very severe exacerbations of the disease and is associated with increased neutrophil influx and interleukin (IL)-8 levels during exacerbations [2]. Here, CXCL8 is linked to chronic obstructive pulmonary disease.