Investigators then proceeded to identify the molecular pathways and mRNAs affected by the deregulated miRNAs and were able to demonstrate through transient transfection and luciferase experiments that BRAF/MAPK regulated miRNAs converge on a complex combinatorial control of a specific set of key cancer regulatory genes involved in cell cycle/proliferation, adhesion/invasion, signaling and survival [70]. This evidence concerns the gene BRAF and cancer.