Table 1 lists the most representative deregulated microRNAs in melanoma subdivided on the basis of the different studies analyzed: i) Group 1 - miRNA signature associated with early progression of melanoma by a in the large profiling approach described by Muller et al [43]; ii) Group 2 - miRNAs deregulated in melanomas vs melanocytes by Caramuta et al and Chan et al. [44, 45]; iii) Group 3 -miRNAs resulted to be deregulated by studies involving individual miRNAs [55–65]; iv) Group 4- miRNA signature associated specifically with BRAF activation and identified by Couts et al [70]. This evidence concerns the gene BRAF and melanoma.