The pooled standard mean deviation (SMD) indicated that NEAT1 was down-regulated in esophageal carcinoma (ESCA, SMD = −0.35, 95% CI: −0.5~-0.20, P < 0.0001) and hepatocellular carcinoma (HCC, SMD = −0.47, 95% CI: −0.60~-0.34, P < 0.0001), while in pancreatic cancer (PC), NEAT1 was up-regulated (SMD = 0.45, 95% CI: 0.2~0.71, P = 0.001). The gene discussed is NEAT1; the disease is pachyonychia congenita.