A study focused on testicular non-seminomatous germ cell tumors (NSGCT) revealed that the risk of treatment failure in patients with metastatic NSGCT was increased when RBM3 was lowly expressed, which suggested that RBM3 was a potential predictor for treatment in patients with metastatic NSGCT [31]. This evidence concerns the gene RBM3 and nongerminomatous germ cell tumor.