Among TAM family members, AXL overexpression is most prominent in various tumor models [34–37] and its inhibition was shown to reduce tumorigenesis and metastasis in several experimental models both in culture and in mice, including breast and lung [30, 31, 35, 38] Acute Myeloid Leukemia [39], head and neck and oral squamous cell carcinomas [3–6, 31, 35]. This evidence concerns the gene AXL and oral cavity squamous cell carcinoma.