Genes in the mevalonate pathway (ACAT2, HMGCS1, and HMGCR) and downstream in the cholesterol biosynthetic pathway (FDPS, FDFT1, and SQLE), were all downregulated in dense NHAs but not dense glioma TS lines (Figure 1G and Supplementary Figure 1E). The gene discussed is HMGCS1; the disease is central nervous system cancer.