Interestingly, while this manuscript was under revision, another group found that activation of the Liver X Receptor via the LXR agonist, LXR-623, is also lethal to glioma cells in cell culture and in orthotopic animal models, presumably via lowering cellular cholesterol levels through the activation of the cholesterol efflux pump, ABCA1 [59]. Here, ABCA1 is linked to central nervous system cancer.