Statins are commonly used cholesterol lowering drugs that inhibit HMGCR in the mevalonate pathway (see Figure 1G), but two different statins, lovastatin and simvastatin, were more toxic to the NHAs than the glioma TS cells, most likely due to their inhibition of not only cholesterol synthesis, but also ubiquinone and dolichol synthesis and prenylation of proteins such as RAS [44] (Supplementary Figure 10A and see Figure 1G). Here, HMGCR is linked to central nervous system cancer.