Genes in the mevalonate pathway (ACAT2, HMGCS1, and HMGCR) and downstream in the cholesterol biosynthetic pathway (FDPS, FDFT1, and SQLE), were all downregulated in dense NHAs but not dense glioma TS lines (Figure 1G and Supplementary Figure 1E). This evidence concerns the gene FDFT1 and central nervous system cancer.