CXCL8 and acne: Fig 2 shows that live and heat-killed S. epidermidis triggered an upregulation of inflammatory molecules such as iNOS, NO, and inflammatory cytokine IL-8 in HaCaT cells. Ce6-mediated PDT notably downregulated the expression of these inflammatory molecules. These results suggest that Ce6-mediated PDT effectively inhibited various inflammatory molecules induced by S. epidermidis and P. acnes which can co-exist in acne lesions.