INS and obesity due to melanocortin 4 receptor deficiency: Indeed, the meta-GWASs and candidate gene studies have successfully identified a considerable list of candidate genes for major depressive disorder,28 bipolar disorder,29 coronary artery diseases,30 type 2 diabetes,31 hypertension,26 obesity,32 plasma lipids level,33 insulin and glucose traits31, 34 and blood pressure.26, 35