These genes belong to interrelated signaling pathways important in the hypotheses of both cardiometabolic diseases and mood disorders: corticotrophin-releasing hormone signaling, AMPK signaling, cAMP-mediated and G-protein-coupled receptor signaling, axonal guidance signaling, serotonin and dopamine receptors signaling, dopamine-DARPP32 feedback in cAMP signaling, leptin signaling and circadian rhythm signaling. This evidence concerns the gene PPP1R1B and mood disorder.