The literature searches in the GWAS catalogue yielded 153 meta-GWA studies for the CMD-Rs: 38 studies for type 2 diabetes, 17 studies for coronary artery disease, 15 studies for hypertension and blood pressure, 26 studies for obesity and BMI, 37 studies for lipids and 20 studies for glucose and insulin traits (Figure 2). This evidence concerns the gene INS and obesity disorder.