In this pathological context, activation of inflammasomes has been described in microglia, macrophages and astrocytes,47 reviewed by Walsh et al.53 Interestingly, post-mortem frontal cortex obtained from BD patients shows a high amount of NLRP3 proteins (NLRP3 being a close relative to NLRP2), in comparison to bio-samples from healthy individuals.46 The presented highly significant difference in the NLRP2 transcriptome expression at the iPSC and NSC stages in our BD I patients cells indicates that inflammation-related process already starts at the very early embryonic development. This evidence concerns the gene NLRP3 and Behcet disease.