Persistent abnormalities in dopaminergic and GABAergic neurotransmitter systems in neuronal progeny might lead to aberrant functional brain oscillatory patterns within brain networks in patients with BD and major depressive disorder (MDD).56 Moreover, ontogeny of cells expressing dopamine and/or GABA receptors have not been clearly demonstrated in human NSC, but genes like neurogenin2 and Nurr1 are expressed in mouse NSC, which could start to differentiate into both pathways.57, 58. Here, NR4A2 is linked to major depressive disorder.