Additionally, bioinformatics analyses by Henderson et al. revealed that the proto-oncogene, PIK3CA, was frequently mutated in tumor types expressing high APOBEC mRNA levels such as HPV-positive CESC and HNSCC (cervical squamous cell carcinoma and endocervical adenocarcinoma and head and neck squamous cell carcinoma) [125]. The gene discussed is PIK3CA; the disease is cervical squamous cell carcinoma.