Individuals inflicted with Werner’s Syndrome (deficiency in WRN helicase), Bloom’s Syndrome (deficiency in BLM helicase), Schimke immuno-osseous dysplasia (deficiency in SMARCAL1), or germline mutations in the RECQL gene display elevated incidence of cancer [62,63,64,65], suggesting that the genome instability associated with these defects can lead to cancer-promoting genetic alterations. This evidence concerns the gene RECQL and cancer.