For PGRMC1 and HADH, their associations ranked at the top 5% (i.e., U-score ≤ 0.05) in the six diabetes studies and their best U-scores were 0.34% and 0.44% in the diabetes studies 9 and 11 of the pancreas, respectively (Table 2). The gene discussed is PGRMC1; the disease is diabetes mellitus.