INS and early-onset autosomal dominant Alzheimer disease: The pathway enrichment analyses showed that the “chronic myelogenous leukemia” had adjusted p-value < 0.05 in five diabetes expression studies of adipose, arteries, blood and pancreatic tissues with effect = 2.87%–7.07% and the insulin response study of skeletal muscles with effect = 4.63% (Supplementary Table S4); the “Alzheimer’s disease” had adjusted p-value < 0.05 in four diabetes studies of arteries, blood and pancreatic tissues with effect = 3.10%–4.06% (Supplementary Table S7).