The six significant gene sets were mainly observed in diabetes studies 1, 2, 3, 4, 8, 10 and 11 and insulin studies 3 and 4 (adjusted p-value < 0.05), involving tissues of adipose, arteries, blood, myotube, pancreatic tissues and skeletal muscles (Supplementary Tables S3–S8 and the Supplementary Figures S1–S6). This evidence concerns the gene INS and diabetes mellitus.