Hepatitis B virus infection is initiated via interaction of the “a” determinant(s) with heparan sulfate proteoglycans (HSPG, low affinity), resulting in a large envelope protein being able to bind to sodium-taurocholate cotransporting polypeptide (NTCP, high affinity) facilitating viral entry [10,11]. Here, SLC10A1 is linked to hepatitis B virus infection.