The top ranked pathways in Additional file 2_C, such as TNF alpha, PDGFR-beta signaling, TGF beta Receptor, VEGFR1 and VEGFR2 signaling, regulation of telomerase, hepatocyte growth factor receptor signaling, ErbB1 downstream signaling and mTOR signaling pathways, may be the key players in the symptoms of schizophrenia. The gene discussed is TNF; the disease is schizophrenia.