Of the 308 overlapped genes from PsyGeNET and SCZCGs, the most frequently appeared (> = 7 psychiatric disorders) genes are DRD2, TPH2, S100B, GAD1, DTNBP1, GFAP and CARTPT among different psychiatric disorders such depressive disorder, bipolar disorder, alcoholism, cocaine-related disorders and suicide. The gene discussed is S100B; the disease is psychiatric disorder.