Because the above mentioned data suggest that SHP activation by ISO-COOH accelerates the resolution of liver fibrosis in the CCl4 model only when administered in combination with CDCA, as a booster for SHP expression in vivo, we have designed a further investigation to dissect the relative contribution of these two agents in protecting against fibrosis development in mice exposed to ANIT. This evidence concerns the gene NR0B2 and Hepatic fibrosis.