Current therapeutic targets for stroke treatment play variety of biological function in stroke process, such as, acetylcholinesterase (AChE), angiotensin I converting enzyme 2 (ACE2), P2Y purinoceptor 12 (P2Y12), postsynaptic density protein 95 (PSD-95), peroxisome proliferator-activated receptor gamma (PPAR-γ), plasminogen activator inhibitor-1 (PAI-1). This evidence concerns the gene SERPINE1 and Stroke.