While in the cortical tissues caveolin-1 showed mRNA changes similar to that observed in the TJPs gene expression experiment (Fig. 3C), in the striatal counterpart a significant up-regulation was detected at early-symptomatic stage (early-HD) concomitantly to first traces of FITC-Albumin extravasation (Figs 2 and 3D). The gene discussed is ALB; the disease is Huntington disease.