NLRP3 and glomerulosclerosis: Moreover, compared to WT + saline mice, WT + IgAN mice showed significantly increased levels of glomerular proliferation, glomerular sclerosis and periglomerular mononuclear leukocyte infiltration by light microscopy on days 14 and 36, and the severity of these renal lesions was greatly reduced in NLRP3 KO + IgAN mice (Fig. 6d,e).