Schmutzler et al. (60) (2002) studied the involvement of RA and RAR in the transcription of NIS using human follicular thyroid carcinoma cell lines and found a dimeric retinoic acid responsive site (DR10) at -1375 relative to the ATG start codon of the human NIS gene. This evidence concerns the gene SLC5A5 and thyroid gland follicular carcinoma.