Thus, the function of NIS -as the key transporter of iodide- has emerged as a valuable tool for the diagnosis and treatment of thyroid cancer, and for decades radioactive iodide played a major therapeutic role in the postoperative management of differentiated thyroid carcinoma (DTC) because of its effectiveness to ablate remnant thyroid tissue and metastases. Here, SLC5A5 is linked to differentiated thyroid carcinoma.