IRF6 and otofaciocervical syndrome 1: 2009; Grant et al. 2009; Beaty et al. 2010; Mangold et al. 2010; Ludwig et al. 2012; Leslie et al. 2016); these studies increased the evidence pointing to IRF6 as a clefting gene. Furthermore, GWAS studies validated the assumption that common variant in IRF6 are associated with nonsyndromic clefts. In addition, a GWAS recently confirmed significant association for SNPs in FOXE1, thus providing evidence that this gene is involved in nonsyndromic OFC etiology (Ludwig et al. 2014).