Further, therapeutic blockade of immune checkpoints by blocking antibodies against CTLA-4 or PD-1 has been shown to produce a broad and beneficial clinical outcome in hematological malignancies [20], as well as improving the potency of CAR-T-cell or TCR-T-cell-based therapies [11, 81, 99, 100]. The gene discussed is CTLA4; the disease is hematologic disorder.