These cells can inhibit the response of leukemia-specific CTLs to the malignant cells by secreting soluble factors including inhibitory cytokines, such as interleukin-4 (IL-4), IL-10, and transforming growth factor β (TGF-β), as well as chemokines CCL22, CCL17, and CCL5 [45, 46]. The gene discussed is IL4; the disease is leukemia.