VEGFA and cancer: The hypoxic environment of cancers induces expression of proteins such as hypoxia-inducible factor-1alpha (HIF-1α) that can regulate expression of angiogenic growth factors like vascular endothelial growth factor (VEGF) [14, 15], though a wide variety of other proteins such as cytokines, interleukins, and other growth factors also contribute to angiogenesis for cancer proliferation [15].