CD8A and cancer: Other mechanisms implemented by the γδ T cells for regulating cancer progression involve secretion of IFN-γ that can activate NK or CD8+ T cells for tumor lysis, recognition of tumor-associated antigens by CD16 (Fc receptor) to mediate antibody-dependent complement cytotoxicity, and the ability of γδ T cell receptors to bind to self-antigens such as heat shock proteins that are upregulated in the cancer microenvironment [44].