LIMK1 and Cognitive impairment: In conclusion, the study indicated that EA at the DU20 and DU24 acupoints could ameliorate cognitive impairment of MICD rats through the regulation of synaptic-dendritic plasticity of the hippocampal CA1 area, and the expression and phosphorylation of synaptic LIMK1 protein were activated to control dendritic spine number, size, and shape.