HMGB1 and neoplasm: Radiation-induced changes in TME elicit in situ vaccination by causing immunogenic cell death through release of factors from dying tumor cells including HMGB1 [13], ATP [14], calreticulin [15], complement [16], and tumor associated antigen (TAA), which activate TAA presentation by dendritic cells (DC) and priming of tumor specific CD8+ cytotoxic T lymphocytes (CTLs) [1, 2, 10, 17–19].