In the context of personalized treatment as a key strategy in the management of patients with type 2 diabetes, the increasing availability of glucagon-like peptide (GLP) 1 receptor agonists with different pharmacokinetic properties means that the appropriateness of the drug considered should be based on a series of factors: the patient’s specific needs and characteristics, pharmacokinetic properties, antihyperglycemic efficacy, effects on associated processes, and safety profile. Here, GLP1R is linked to type 2 diabetes mellitus.