Interestingly, Kwon et al. [156] reported that Hh signalling can promote liver inflammation through OPN-mediated macrophage activation contributing to NAFLD progression, while the inhibition of Hh signalling can ameliorate hepatic inflammation in mice with NAFLD, highlighting the therapeutic propensity of Hh inhibitors [156]. The gene discussed is SPP1; the disease is metabolic dysfunction-associated steatotic liver disease.