TNF and cancer: As transcription of TNF-α is regulated under genetic control, recent studies have shown that its promoter polymorphisms at TNF-α G-238A (rs361525), TNF-α G-308A (rs1800629), TNF-α T-857C (rs1799724), and TNF-α T-1031C (rs1799964) positions could regulate TNF-a production, thus affecting the risk of cancers [4–7].