In all subjects, meta-analysis showed an increased risk between the TNF-α T-857C polymorphism and gastric cancer susceptibility in three genetic models (T versus C: OR = 1.12, 95% CI = 1.01–1.25, P = 0.04, I2 = 0%, fixed-effects model; TC versus CC: OR = 1.16, 95% CI = 1.02–1.33, P = 0.02, I2 = 0%, fixed-effects model; TT + TC versus CC: OR = 1.16, 95% CI = 1.02–1.32, P = 0.02, I2 = 0%, fixed-effects model, Figure 2). Here, TNF is linked to gastric cancer.