AR is the predominant form of rhinitis in children, but also accounts for one-third of adult cases.1 At greatest risk are those with a personal or family history of atopy (defined by positive skin prick tests or specific IgE to common aeroallergens).2 The clinical history should determine whether allergy testing is required, which may be useful to identify or exclude an allergic trigger that may influence management, e.g., aeroallergen avoidance. The gene discussed is IGHE; the disease is allergic disease.