IGHE and asthma: CysLTs can also be generated by other cells of the innate immune system, such as basophils, eosinophils, and alveolar macrophages, after exposure to allergens, proinflammatory cytokines, and other stimuli during allergic inflammation and also transcellularly by platelet-adherent leukocytes in patients with aspirin-exacerbated asthma.9, 29, 37 Therefore cysLTs can contribute to IgE-independent innate responses of ILC2s.