IL2 and asthma: In vivo, it has been reported that IL-2 is a cofactor in regulating ILC2 function in pulmonary inflammation and coordinating type 2 cytokine expression in mouse models.28, 44 Increased levels of IL-2 were detected in the lungs of asthmatic patients, and inhaled IL-2 therapy has been shown to induce asthma-like airway inflammation.45