CYSLTR1 and asthma: Several studies have shown an improvement of atopic dermatitis after treatment with CysLT1 antagonists.31, 32, 33 Furthermore, a significantly higher concentration of LTE4 was detected in urine of patients with atopic dermatitis or asthma and in sputum from patients with asthma compared with healthy volunteers.34, 35, 36 Collectively, these findings suggest that LTE4-mediated ILC2 activation could be a critical contributor to allergic inflammation.