To check the diabetogenic nature of OPs, animals treated with 10× TMDI dose of OPs for a chronic time period resulted in significant glucose intolerance (Fig. 2a and c) and oxidative stress (Fig. 2d and Additional file 1: Figure S8) leading to hepatic damage (Additional file 1: Figures S7F and S8E) with no change in AChE activity (Fig. 2b). This evidence concerns the gene ACHE and Glucose intolerance.