We have established (in serum-free medium) two CRC-pc organoid cultures of peritoneal metastatic lesions from two CRC patients that showed enrichment in the expression of the CRC CSC marker leucine-rich repeat containing G protein-coupled receptor 5 (LGR5) a member of the canonical WNT pathway and a well-recognized marker of the cell progenitor population located at the crypt-base [4, 5]. Here, LGR5 is linked to colorectal carcinoma.