Cordycepin was reported to inhibit α-MSH and IBMX induced melanin biosynthesis by inhibiting melanin synthesis related enzymes, such as tyrosinase, TRP-1, and TRP-2, suppressing CREB and MITF activity, and activating the PI3K/AKT pathway in B16F10 melanoma cells [43]. This evidence concerns the gene CREB1 and melanoma.