Multivariate Cox analysis was further performed and suggested high CCR7 expression as an independent adverse prognostic factor for mRCC patients’ OS prediction (HR 2.256, 95% CI 1.336–3.809, P = 0.002; P = 0.003 after 1000 bootstrap), together with tumor histology and Heng’s risk group (Table 2). This evidence concerns the gene CCR7 and neoplasm.