Since the CCR7 mediated lymphatic specific migration and metastasis was also based on several above mentioned programmes [8, 29], and as a molecule which could give tumor itself survival signal besides [30], we hypothesized that CCR7 positive RCC cells might have a potential to migrate into the adjacent lymphatic tissue for survival after TKI drugs administration, subsequently leading to resistance and disease progression. Here, CCR7 is linked to renal cell carcinoma.