As for the pathological diagnosis (p = 0.04), the rate of TFDP3 expression was 75% in invasive lobular carcinoma (3 in 4 cases), 40.28% in invasive ductal carcinoma (29 in 72 cases) and 16.67% in adenosis (1 in 6 cases), while there was no TFDP3 staining detected in fibroadenoma (0 in 6 cases), plasma cell mastitis (0 in 6 cases) or normal breast tissue (0 in 2 cases) (Fig 4A). The gene discussed is TFDP3; the disease is invasive lobular breast carcinoma.