Reportedly, hepatocellular carcinomas (HCCs) with stemness features, which express hepatic stem cell (HSC) markers, such as keratin19 (K19), CD133, or epithelial cell adhesion molecule (EpCAM), are associated with a higher incidence of vascular invasion and poorer prognosis, compared to HCCs lacking these markers [2, 3]. This evidence concerns the gene EPCAM and hepatocellular carcinoma.