MUC5AC and parasitic infectious disease: This is consistent with a recent report by Nunes et al. demonstrating that in vivo administration of T. cruzi mucin during murine experimental infection with T. cruzi parasites resulted in a lower number of splenic IFN-γ producing CD4 T cells [46], with these effects being accompanied by a greater susceptibility to infection, as shown by the higher levels of parasitemia [46].