AURKA and breast cancer: It was originally identified as a mitotic kinase, which has essential roles in control of centrosome maturation/separation, bipolar spindle formation and G2/M progression to ensure the fidelity of mitosis.4 The role of AURKA in cancer is underscored by the fact that it is amplified and overexpressed in a multitude of human tumour types.32 In breast cancer, AURKA is amplified in about 12% of all primary tumours32 and its mRNA overexpressed in 62% of breast carcinomas.33 In addition, overexpression of AURKA is also observed in 94% of invasive ductal adenocarcinomas of the breast.34