Meanwhile, HOXA-AS2 can also suppress the expression of KLF2 (a tumor suppressor and the member of KLF family with Cys2/His2 zinc-finger domains).36 The p21 and KLF2 mRNA and protein expression was significantly increased after HOXA-AS2 expression was altered in the CRC cells, indicating that p21 and KLF2 may be the possible target of HOXA-AS2. The gene discussed is CDKN1A; the disease is colorectal carcinoma.