NGFR and metastatic melanoma: To further assess whether expression of CD271-responsive genes may not only promote chemoresistance but also metastasis formation, we took advantage of publicly available expression profiling data of primary (n=31) and metastatic melanoma (n=52).35 Exploration of the set of upregulated genes (n=1054, >2-fold, P⩽0.05) revealed the presence of 110 CD271-responsive genes, upregulated in melanoma metastases (Figure 5e and Supplementary Table S7).