DMBT1 expression is frequently lost in lung cancer39 and glioblastoma.40 We observed a strong upregulation of both genes upon knock-down of CD271 in MeWo derivatives and T20/02 cells (Supplementary Figures S6D and E), suggesting that CD271 expression leads to repression of both metastasis inhibitors, facilitating melanoma metastasis. Here, DMBT1 is linked to melanoma.