For example, studies of kisspeptin administration in patients with depression and psychosexual disorders may prove fruitful as well as informing current work to develop kisspeptin as a potential therapeutic for common reproductive disorders, including male hypogonadism (56), hypothalamic amenorrhoea (54), and hyperprolactinaemia (63), and as a trigger for ovulation in in vitro fertilization (53). This evidence concerns the gene KISS1 and depressive disorder.