Recent work has shown that signaling targets of ceramide are not affected by similar levels of dhCer, which suggests that the enzyme DEGS is essential in cell regulation31 and plays a role on glucose homeostasis as well: multiple SNPs in DEGS are significantly associated with 2 hour glucose, mice lacking DEGS are resistant to dexamethasone-induced insulin resistance and DEGS-knockdown mice myoblast are protected from palmitate-induced ceramide-mediated insulin resistance22, 28, 29, 32. This evidence concerns the gene DEGS1 and Insulin resistance.