CAV1 and posterior cortical atrophy: In future studies we finally aim to specify the role of Cav1 alterations potentially induced by the Cav1-deficient and more reactive stroma for the radiosensitivity of PCa on molecular level, in particular to identify Cav1-dependent fibroblastic secreted factors which potentially foster the observed Cav1 re-expression in the malignant epithelial cells.