Finally (vii) similar to the Cav1-alterations, immunoreactivity of phosphoCav1 and the Cav1 phosphorylating kinase Src clearly increased in the malignant epithelial cells of the more radioresistant higher Gleason grade human prostate adenocarcinomas which was paralleled by a more reactive Cav1-deficient tumor stroma, and thus confirms the importance of Src signaling as a potential candidate for future Cav1-mediated radiation response modulation. The gene discussed is CAV1; the disease is neoplasm.