To mimic the human situation we performed co-implantations of Cav1-silenced PC3(−) tumor cells in combination with Cav1-silenced or Cav1-expressing HS5 fibroblasts by subcutaneous transplantations onto the hind limb of NMRI nude mice and irradiation treatment after manifestation of the tumor (Fig. 6). Here, CAV1 is linked to neoplasm.