CAV1 and posterior cortical atrophy: Although the authors did not investigate possible Cav1 presence in this exosomes, it is a quite promising observation since the alterations of Cav1 observed by us and others during PCa progression, maybe either based on direct transfer of Cav1 via those vesicles between malignant epithelial cells and stromal fibroblasts or might be fostered via the transfer of Cav1 regulating components like Src.