EPAS1 and Hepatic fibrosis: In the CCl4 groups, the effect of HIF-2α silencing in attenuating liver fibrosis was significantly higher compared with the effect of silencing HIF-1α, however, silencing HIF-1α plus HIF-2α did not achieve a greater attenuation of fibrosis than silencing HIF-2α alone (p = 0.280).