CD44 and posterior cortical atrophy: As miR-141 was also under-expressed in CD44+ PCa (Fig. 1a) and HPCa (Fig. 1c) cells, and there was a good inverse correlation between % CD44+ PCa cells and relative miR-141 levels (Fig. 1b), we suspected that miR-141 might also target CD44. Indeed, several miRNA target prediction programmes identified a putative miR-141 binding site in the 3′-UTR of CD44 that partially overlapped with and localized just slightly downstream of the second miR-34a-binding site (Fig. 3d).