AR and posterior cortical atrophy: To determine molecular mechanisms underlying the metastasis-suppressing effects of miR-141 in PCa cells, we performed Matrigel invasion assays, which revealed that miR-141 significantly inhibited invasive capabilities of several different types of PCa cells including AR− (DU145 and PC3; Supplementary Fig. 4a,b), primary patient HPCa (Supplementary Fig. 4c,d) and AR+ (VCaP, LAPC4 and LNCaP C4-2; Supplementary Fig. 4e) PCa cells.