RAC1 and posterior cortical atrophy: As our RNA-Seq analysis implicated RAC1, CDC42, CDC42EP3 and ARPC5 as direct miR-141 targets in PCa cells (Fig. 4l and Supplementary Fig. 7a–h), we performed western blotting (WB) analysis to determine the impact of miR-141 on the protein levels of these four molecules.