IGF1 and Familial prostate cancer: Ingenuity Pathway Analysis (IPA) in the 2,253 DEGs revealed ‘prostate cancer signalling' and several growth factor signalling pathways including PI3K/AKT, ERK/MAPK, IGF-1/insulin receptor and epidermal growth factor/ERBB, and growth hormone signalling among the pathways most significantly affected by miR-141 (Fig. 4b).