PRDM9 and medical procedure: Interestingly, IPA upstream regulator analysis implicated EZH2, a histone methyltransferase and a critical component of the PRC2 (polycomb repressive complex 2) that is frequently overexpressed in aggressive forms of prostate and other cancers, and involved in CSC maintenance, invasion and metastasis43, 44, 45, 46, as a miR-141 ‘upstream regulator' (P=2.46 × 10−7), suggesting that EZH2 might be one of the mediators in miR-141-elicited global gene changes.