We also registered an increase in the nuclear accumulation of GLI1 and GLI2 in cells silenced stably for Merlin (Fig. 3C; Supplementary Figure 6A) clearly demonstrating that not only were the levels of GLI increased, but also the nuclear accumulation of GLI transcription factors was greater when tumor cells are modulated for Merlin deficiency. The gene discussed is GLI2; the disease is neoplasm.