DAVID GO analysis40 identified 12 enriched molecular pathways in AR− luminal cells (FDR <0.1; Supplementary Data 3), with the most notable ones implicated in cell-matrix adhesions, MAPK and TGF-β signalling pathways, prostate cancer and cytoskeleton regulation (Fig. 4e). This evidence concerns the gene TGFB1 and prostate carcinoma.