Moreover, we extended these studies to explore the ALL-MSC ability of intercommunicating to HSPC by evaluating the display of the major adhesion VLA-4/VCAM-1 axis and found a substantial reduction of VLA-4 expression by ALL hematopoietic MNC, as well as decreased VCAM-1 expression by ALL-MSC. Here, VCAM1 is linked to acute lymphoblastic leukemia.