Here, our data indicate a correspondence in the phenotype of the MSC from ALL and NBM, showing minor differences in expression of HLA-ABC, CD13, CD73, CD140b, CD44, CD54, CD49b, and CD166, which may relate to potential abnormalities in the capacity of cell–cell intercommunication with leukemic precursors within the BM. This evidence concerns the gene CD44 and acute lymphoblastic leukemia.