Differentiation gene transcripts, including Runx2 (osteogenesis), Sox9 (chondrogenesis), and PPARG2 (adipogenesis) revealed a substantial reduction in Sox9 expression by ALL cells, suggesting altered lymphopoiesis associated to defects in osteochondrogenesis (Figure 1F) as reported (34). Here, RUNX2 is linked to acute lymphoblastic leukemia.